The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 27, 2021
Filed:
Oct. 11, 2017
Industrial Cooperation Foundation Chonbuk National University, Jeollabuk-do, KR;
Uh Hyun Kim, Jeollabuk-do, KR;
Dae Ryoung Park, Jeollabuk-do, KR;
Kwang Hyun Park, Jeollabuk-do, KR;
Industrial Cooperation Foundation Chonbuk National University, Joellabuk-do, KR;
Abstract
When using a pharmaceutical composition for preventing or treating malignant hyperthermia, containing NAADP antagonists, of the present invention, malignant hyperthermia can be effectively prevented or treated through the inhibition of an oxygen consumption rate abnormal increase, which is associated with a ryanodine receptor (RYR) of skeletal muscles. In addition, the present invention can be used even after the onset of malignant hyperthermia and can inhibit an oxygen consumption rate abnormal increase even at concentrations lower than those of conventional agents for treating malignant hyperthermia, thereby enabling conventional agents for treating malignant hyperthermia to be replaced, and can be stably used, thereby being effectively usable in relevant industries. Furthermore, when using a skin regenerating composition, containing cADPR or NAADP antagonists, of the present invention, the skin can be protected from skin cell damage caused by UV-B of ultraviolet rays, and the skin regenerating composition has an excellent ability to recover and regenerate damaged skin and has no side effects on the same, thereby being usable in various forms such as a skin external preparation, a pharmaceutical composition, a cosmetic composition, and a food composition.