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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11066457 B1

PDFFull Text
Date of Patent:
Jul. 20, 2021

Filed:

Feb. 08, 2018

Construction of chimeric antigen receptor targeting cd20 antigen and activity identification of engineered t cells thereof

Applicant:

Cellular Biomedicine Group HK Limited, Hong Kong, CN;

Inventors:

Yihong Yao, Shanghai, CN;

Jiaqi Huang, Shanghai, CN;

Shigui Zhu, Shanghai, CN;

Wei Zhu, Shanghai, CN;

Xin Yao, Shanghai, CN;

Zhiyuan Li, Shanghai, CN;

Li Zhang, Shanghai, CN;

Lin Zhu, Shanghai, CN;

Anyun Ma, Shanghai, CN;

Yutian Wei, Shanghai, CN;

Yanfeng Li, Shanghai, CN;

Qingxia Wang, Shanghai, CN;

Jiaping He, Shanghai, CN;

Assignee:

CELLULAR BIOMEDICINE GROUP HK LIMITED, Hong Kong, CN;

Attorney:

Leason Ellis LLP

Primary Examiner:

Ilia I Ouspenski

Int. Cl.
CPC ...
A61K 35/17 (2015.01); A61P 35/02 (2006.01); C12N 5/10 (2006.01); C07K 16/28 (2006.01); C12N 15/62 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); A61P 35/00 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01); C07K 19/00 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/17 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 16/2887 (2013.01); C07K 19/00 (2013.01); C12N 5/10 (2013.01); C12N 7/00 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01); C12N 2740/15043 (2013.01);
Abstract

Provided are a chimeric antigen receptor targeting CD20 antigen and a preparation method thereof. The extracellular antigen binding domain of the chimeric antigen receptor includes an antibody heavy chain variable region shown in SEQ ID NO: 7 or 9 or 33 and an antibody light chain variable region shown in SEQ ID NO: 11 or 13 or 35, and is capable of killing tumor cells.

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