The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Feb. 24, 2017
Applicant:
Washington University, St. Louis, MO (US);
Inventors:
Marco Colonna, St. Louis, MO (US);
Yarning Wang, St. Louis, MO (US);
Marina Celia, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61P 25/28 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12Q 1/68 (2018.01); C07K 16/46 (2006.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); A61K 38/177 (2013.01); A61P 25/28 (2018.01); C07K 16/2803 (2013.01); C07K 16/46 (2013.01); C12N 15/62 (2013.01); C12Q 1/68 (2013.01); C07K 2317/76 (2013.01); C07K 2319/01 (2013.01); C07K 2319/30 (2013.01);
Abstract
The present invention provides TREM2 constructs. TREM2 constructs of the invention are polynucleotide sequences encoding a polypeptide, wherein the polypeptide comprises at least one TREM2 or fragment thereof and a targeting moiety and optionally comprising a signal peptide and/or a purification moiety. The present invention also provides isolated polypeptides encoded by TREM2 constructs, vectors comprising TREM2 constructs, isolated cells comprising said vectors, and methods of use thereof.