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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11066441 B1

PDFFull Text
Date of Patent:
Jul. 20, 2021

Filed:

Sep. 14, 2016

Method for separating and purifying α2-macroglobulin from cohn fraction iv precipitation

Applicant:

Academy of Military Medical Sciences, Beijing, CN;

Inventors:

Yuyuan Ma, Beijing, CN;

Chaoji Huangfu, Beijing, CN;

Xiong Zhao, Beijing, CN;

Maomin LV, Beijing, CN;

Jingang Zhang, Beijing, CN;

Junting Jia, Beijing, CN;

Assignee:

ACADEMY OF MILITARY MEDICAL SCIENCES, Beijing, CN;

Attorney:

Scully, Scott, Murphy & Presser, P.C.

Primary Examiner:

Katherine Zalasky McDonald

Int. Cl.
CPC ...
C07K 1/36 (2006.01); C07K 1/14 (2006.01); C07K 1/22 (2006.01); C07K 1/34 (2006.01); B01D 15/38 (2006.01); B01D 15/12 (2006.01); B01D 15/34 (2006.01); B01D 15/42 (2006.01); C07K 14/81 (2006.01);
U.S. Cl.
CPC ...
C07K 1/36 (2013.01); B01D 15/12 (2013.01); B01D 15/34 (2013.01); B01D 15/3828 (2013.01); B01D 15/426 (2013.01); C07K 1/14 (2013.01); C07K 1/22 (2013.01); C07K 1/34 (2013.01); C07K 14/81 (2013.01); C07K 14/8107 (2013.01);
Abstract

The present invention discloses a method for separating and purifying α2-macroglobulin from Cohn Fraction IV precipitation, in which Cohn Fraction IV precipitation is treated by ammonium sulfate precipitation, zinc ion affinity chromatography, gel filtration, and ultrafiltration and concentration sequentially and thereby α2-macroglobulin is obtained finally. With the method provided in the present invention, purified α2-macroglobulin plasma protein that has a clinical application value is obtained, the Cohn Fraction IV precipitation is changed from a discarded material into a valuable material, and plasma is utilized comprehensively. In addition, the method is easy and simple to use, easy to scale up, and suitable for separation and purification of α2-macroglobulin at a large scale.

Find Patent Forward Citations

Ma, Yuyuan. (2021). Method for separating and purifying α2-macroglobulin from cohn fraction iv precipitation (U.S. Patent No. 11066441). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11066441

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