The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Mar. 24, 2021
Applicant:
Uppthera, Incheon, KR;
Inventors:
Soo Hee Ryu, Incheon, KR;
Hwa Jin Lee, Incheon, KR;
Seong Hoon Kim, Incheon, KR;
Hye Guk Ryu, Incheon, KR;
Eun Bin Lee, Incheon, KR;
Assignee:
UPPTHERA, Incheon, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01);
Abstract
The present invention relates to bifunctional compounds that induce HMG-CoA reductase degradation, in which in which atorvastatin and E3 ubiquitin ligase binding moiety are chemically linked. The present invention also relates to a preparation method of the compounds, a method for degrading HMG-CoA reductase using the compounds, and a composition for the prevention or treatment of HMG-CoA reductase-related diseases comprising the compounds.