The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 20, 2021
Filed:
Nov. 19, 2019
Applicant:
Trustees of Tufts College, Medford, MA (US);
Inventors:
William W. Bachovchin, Cambridge, MA (US);
Hung-sen Lai, Andover, MA (US);
Sarah E. Poplawski, Belmont, MA (US);
Assignee:
Trustees of Tufts College, Medford, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/69 (2006.01); A61K 47/64 (2017.01); A61K 47/54 (2017.01); A61K 45/06 (2006.01); G01N 33/574 (2006.01); C07K 5/083 (2006.01); C07K 5/087 (2006.01); C07K 5/097 (2006.01); C07K 5/107 (2006.01); C07K 5/065 (2006.01); C07K 5/062 (2006.01); A61K 38/07 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/64 (2017.08); A61K 31/69 (2013.01); A61K 38/07 (2013.01); A61K 45/06 (2013.01); A61K 47/54 (2017.08); C07K 5/06026 (2013.01); C07K 5/06034 (2013.01); C07K 5/06078 (2013.01); C07K 5/081 (2013.01); C07K 5/0806 (2013.01); C07K 5/0808 (2013.01); C07K 5/0812 (2013.01); C07K 5/0821 (2013.01); C07K 5/1016 (2013.01); G01N 33/574 (2013.01); A61K 38/00 (2013.01);
Abstract
Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and prodrugs and compositions thereof, for example, in treating cancer or other cell proliferative diseases. In vitro and in vivo methods of quantifying the expression of FAP in a biopsy sample and a mammal, respectively, are also disclosed.