The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Oct. 15, 2019
Waters Technologies Corporation, Milford, MA (US);
Martin Gilar, Franklin, MA (US);
Keith Fadgen, Hope Valley, RI (US);
Peyton C. Beals, Wrentham, MA (US);
Sylvain Gilles Cormier, Mendon, MA (US);
Richard Wayne Andrews, Rehoboth, MA (US);
Geoff C. Gerhardt, Woonsocket, RI (US);
Jordan Kornfeld, Norfolk, MA (US);
Thomas S. McDonald, Holden, MA (US);
WATERS TECHNOLOGIES CORPORATION, Milford, MA (US);
Abstract
Described are a method and apparatus for diluting a chromatographic sample. The method includes repeating an alternating acquisition of sample fluidic plugs each having an incremental volume of sample and diluent fluidic plugs each having an incremental volume of diluent to obtain a stack of alternating sample and diluent fluidic plugs. The stack is inserted into a flow of a mobile phase in a chromatography system. Alternatively, the method includes repeating the steps of injecting an incremental volume of sample into a chromatographic system flow and providing an incremental volume of mobile phase into the chromatographic system flow. In either implementation, the dilution ratio of the sample equals the sum of the incremental volumes of the sample and the diluent or mobile phase divided by the sum of the incremental volumes of the sample.