The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Jun. 05, 2018
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Sharon Gerecht, Severna Park, MD (US);
Sravanti Kusuma, Chicago, IL (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/02 (2006.01); C12N 5/071 (2010.01); A61K 38/39 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/069 (2013.01); C12N 5/0691 (2013.01); A61K 31/00 (2013.01); A61K 38/39 (2013.01); C12N 5/0692 (2013.01); C12N 2501/15 (2013.01); C12N 2501/165 (2013.01); C12N 2501/17 (2013.01); C12N 2501/42 (2013.01); C12N 2501/905 (2013.01); C12N 2501/998 (2013.01); C12N 2506/02 (2013.01); C12N 2506/03 (2013.01); C12N 2506/45 (2013.01); C12N 2533/54 (2013.01); C12N 2533/80 (2013.01);
Abstract
The present invention relates to the area of in vitro cell populations useful for generating vascular networks in vitro and are suitable for use in vivo for regeneration of vascular tissue. In some embodiments, the bipotent cell population of the present invention comprise endothelial cells and pericytes that express vascular endothelial cadherin and are 95% or more positive for CD105 and CD146, and which work syergistically to recreate vascular tissues in vitro.