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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11059876 B1

PDFFull Text
Date of Patent:
Jul. 13, 2021

Filed:

Feb. 26, 2019

Il-15 variants and uses thereof

Applicant:

Pfizer Inc., New York, NY (US);

Inventors:

Yik Andy Yeung, South San Francisco, CA (US);

Reid Martin Renny Feldman, San Francisco, CA (US);

Ling Hon Matthew Chu, San Jose, CA (US);

Javier Fernando Chaparro Riggers, San Mateo, CA (US);

Ivana Djuretic, San Bruno, CA (US);

Laura Lin, Weston, MA (US);

Lidia Mosyak, Newton, MA (US);

Assignee:

PFIZER INC., New York, NY (US);

Attorney:

Stephen E. Moyer

Primary Examiner:

Bridget E Bunner

Assistant Examiner:

Fozia M Hamud

Int. Cl.
CPC ...
C07K 14/54 (2006.01); A61K 39/395 (2006.01); A61K 38/17 (2006.01); A61K 38/20 (2006.01); A61K 35/17 (2015.01); C07K 19/00 (2006.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01); C07K 16/28 (2006.01); C07K 14/55 (2006.01); C12N 15/62 (2006.01); A61K 38/19 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5443 (2013.01); A61K 35/17 (2013.01); A61K 38/1793 (2013.01); A61K 38/19 (2013.01); A61K 38/191 (2013.01); A61K 38/2086 (2013.01); A61K 39/395 (2013.01); A61P 35/00 (2018.01); C07K 14/55 (2013.01); C07K 16/283 (2013.01); C07K 16/2815 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/32 (2013.01); C07K 19/00 (2013.01); C12N 15/62 (2013.01); A61K 45/06 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2319/31 (2013.01);
Abstract

The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.

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