The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 13, 2021

Filed:

Dec. 11, 2017
Applicants:

Glaxosmithkline Intellectual Property Development Limited, Brentford, GB;

Astex Therapeutics Limited, Cambridge, GB;

Inventors:

Anthony William James Cooper, Stevenage, GB;

Nicole Cathleen Goodwin, King of Prussia, PA (US);

Charlotte Mary Griffiths-Jones, Cambridge, GB;

Thomas Daniel Heightman, Cambridge, GB;

Jeffrey K. Kerns, King of Prussia, PA (US);

Hendrika Maria Gerarda Willems, Cambridge, GB;

Hongxing Yan, King of Prussia, PA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/553 (2006.01); A61P 9/04 (2006.01); A61P 11/00 (2006.01); C07D 498/04 (2006.01); C07D 419/12 (2006.01); C07D 249/04 (2006.01); C07D 401/12 (2006.01); C07D 419/14 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 419/12 (2013.01); C07D 249/04 (2013.01); C07D 401/12 (2013.01); C07D 419/14 (2013.01); C07D 498/04 (2013.01); C07D 513/04 (2013.01);
Abstract

The present invention relates to ether-linked triazole compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof:


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