The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Oct. 28, 2019
Applicant:
Novartis Ag, Basel, CH;
Inventors:
Michael Joseph Luzzio, Noank, CT (US);
Julien Papillon, Somerville, MA (US);
Michael Scott Visser, Braintree, MA (US);
Assignee:
Novartis AG, Basel, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/497 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); A61P 31/04 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/497 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); A61P 31/04 (2018.01); A61P 35/00 (2018.01); C07D 413/14 (2013.01);
Abstract
PKC inhibitors are disclosed. The PKC inhibitors are useful for treating PKC associated diseases, including certain cancers. The PKC inhibitors have improved efficacy at lower dosage amounts to achieve tumor regression, improved potency, PK profile, absorption, gastrointestinal tolerance and kinase selectivity.