The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Apr. 18, 2017
Applicant:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Inventors:
James B. Flanegan, Gainesville, FL (US);
Robert McKenna, Gainesville, FL (US);
Christopher Daniel Boone, College Station, TX (US);
Sushma Abraham Ogram, Gainesville, FL (US);
Barbara Joan Morasco, Gainesville, FL (US);
Assignee:
University of Florida Research Foundation, Incorporated, Gainesville, FL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/13 (2006.01); C07K 14/005 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); C07K 14/105 (2006.01); A61P 31/14 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/13 (2013.01); A61K 39/12 (2013.01); A61P 31/14 (2018.01); C07K 14/005 (2013.01); C07K 14/105 (2013.01); C12N 7/00 (2013.01); A61K 2039/5258 (2013.01); C12N 2770/32622 (2013.01); C12N 2770/32623 (2013.01); C12N 2770/32634 (2013.01); C12N 2770/32651 (2013.01); Y02A 50/30 (2018.01);
Abstract
Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.