The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Jan. 13, 2016
Keio University, Tokyo, JP;
Makoto Hosoya, Tokyo, JP;
Masato Fujioka, Tokyo, JP;
Hideyuki Okano, Tokyo, JP;
Kaoru Ogawa, Tokyo, JP;
Tatsuo Matsunaga, Tokyo, JP;
Keio University, Tokyo, JP;
Abstract
An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein Rto Rare each independently selected from a hydrogen atom, a halogen atom, or a Calkyl group, a Ccycloalkyl group, a Caryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a Calkyl group, a Calkoxy group, a Calkoxy carbonyl group, a Ccycloalkyl group, a Calkenyl group, a Calkynyl group, and a phenyl group; wherein Ris a Calkyl or a Calkynyl, Ris H, —CH2-OH or —CH—CHOH, and X is ═O, (H, H) or (H, OH).