The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 13, 2021
Filed:
Oct. 15, 2020
Applicant:
King Abdulaziz University, Jeddah, SA;
Inventors:
Assignee:
King Abdulaziz University, Jeddah, SA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/51 (2006.01); A61K 9/06 (2006.01); A61K 9/50 (2006.01); A61K 31/513 (2006.01);
U.S. Cl.
CPC ...
A61K 9/06 (2013.01); A61K 9/5036 (2013.01); A61K 9/5192 (2013.01); A61K 31/513 (2013.01);
Abstract
A sustained-release formulation of 5-fluorouracil (5-FU) providing a polymeric coating in a nanosuspension comprising sodium alginate and carrageenan for oral administration. The nanosuspension forms an insoluble sedimenting gel in the low pH environment of the stomach to speed gastric emptying. The sedimented insoluble gel becomes soluble in the pH environment of the small intestine and is transported to the colon where 5-FU is released at a predictable rate. The targeted delivery to the colon inhibits loss of 5-FU in the gastrointestinal tract and increases 5-FU exposure to cancerous cells in the colon.