The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 06, 2021

Filed:

Jan. 24, 2020
Applicant:

Q32 Bio Inc., Cambridge, MA (US);

Inventors:

Michael Steven Curtis, Waltham, MA (US);

Michael Storek, Cambridge, MA (US);

Shelia Marie Violette, Lexington, MA (US);

Susan L. Kalled, Concord, MA (US);

Kelly C. Fahnoe, Waltham, MA (US);

Cheng Ran Huang, Belmont, MA (US);

Ellen Garber Stark, Cambridge, MA (US);

Frederick Robbins Taylor, Milton, MA (US);

Justin Andrew Caravella, Cambridge, MA (US);

Vernon Michael Holers, Denver, CO (US);

Assignee:

Q32 Bio Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/18 (2006.01); A61P 13/12 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 38/1725 (2013.01); A61P 13/12 (2018.01); C07K 14/472 (2013.01); C07K 2317/51 (2013.01); C07K 2317/565 (2013.01); C07K 2319/00 (2013.01);
Abstract

Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.


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