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For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11053234 B1

PDFFull Text
Date of Patent:
Jul. 06, 2021

Filed:

Oct. 12, 2017

1,3 di-substituted cyclobutane or azetidine derivatives as hematopoietic prostaglandin d synthase inhibitors

Applicant:

Glaxosmithkline Intellectual Property Development Limited, Brentford, GB;

Inventors:

David Norman Deaton, Collegeville, PA (US);

Yu Guo, Collegeville, PA (US);

Ashley Paul Hancock, Stevenage, GB;

Christie Schulte, Collegeville, PA (US);

Barry George Shearer, Collegeville, PA (US);

Emilie Despagnet Smith, Apex, NC (US);

Eugene L. Stewart, Collegeville, PA (US);

Stephen Andrew Thomson, Del Mar, CA (US);

Assignee:

GlaxoSmithKline Intellectual Property Development Limited, Middlesex, GB;

Attorney:

Stanek Lemon Crouse & Meeks, PA

Primary Examiner:

Paul V Ward

Int. Cl.
CPC ...
C07D 417/14 (2006.01); C07D 417/12 (2006.01); C07C 235/40 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); C07D 205/04 (2006.01); C07D 401/04 (2006.01); C07D 239/42 (2006.01); C07D 271/10 (2006.01); C07D 257/06 (2006.01); C07D 403/04 (2006.01); C07D 277/44 (2006.01); C07D 277/62 (2006.01); A61P 21/00 (2006.01); A61P 11/06 (2006.01); C07D 215/24 (2006.01); C07D 239/72 (2006.01); C07D 277/64 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 9/0019 (2013.01); A61K 9/48 (2013.01); A61P 11/06 (2018.01); A61P 21/00 (2018.01); C07C 235/40 (2013.01); C07D 205/04 (2013.01); C07D 215/24 (2013.01); C07D 239/42 (2013.01); C07D 239/72 (2013.01); C07D 257/06 (2013.01); C07D 271/10 (2013.01); C07D 277/44 (2013.01); C07D 277/62 (2013.01); C07D 277/64 (2013.01); C07D 401/04 (2013.01); C07D 403/04 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/14 (2017.05); C07C 2602/08 (2017.05); C07C 2603/94 (2017.05);
Abstract

A compound of formula (I) wherein R, R, R, R, Y, Y, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

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