The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2021
Filed:
Jan. 31, 2020
Abx Advanced Biochemical Compounds Gmbh, Radeberg, DE;
René Martin, Dresden, DE;
René Smits, Dresden, DE;
Ronny Hesse, Dresden, DE;
Alexander Hoepping, Dresden, DE;
Marco Müller, Dresden, DE;
Sandra Hübner, Heidenau, DE;
ABX advanced biochemical compounds GmbH, Radeberg, DE;
Abstract
A method for producing a radiofluorinated compound having an aromatic or heteroaromatic ring carrying [F] fluorine as first substituent, a bonding unit, which can bind to a peptide or peptide mimetic, and a spacer group connected via bond Ato the bonding unit and via bond Ato the ring, wherein the bonding unit has second substituent(s) —OH, —CONH, and/or —COOH. The steps include (a) providing a precursor having the ring carrying a substituent Y, bonding unit with the second substituent(s), and spacer group, wherein substituent Y is —N(RRR), —NO, —Cl, —Br, —F, or —I, and R, R, and Rare independently C-Calkyl; and (b) reacting the precursor with a [F] fluoride anion in the presence of an activation salt to the radiofluorinated compound, which has a cation N(RRRR) with R, R, R, and Rbeing independently C-Calkyl, wherein the substituent Y is replaced by [F] fluoride.