The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 06, 2021

Filed:

Sep. 28, 2017
Applicant:

Global Life Sciences Solutions Usa Llc, Marlborough, MA (US);

Inventors:

Andreas Castan, Uppsala, SE;

Colin R. Tuohey, Marlborough, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 2/00 (2006.01); C12N 5/00 (2006.01); C12N 13/00 (2006.01);
U.S. Cl.
CPC ...
A61L 2/0017 (2013.01); A61L 2/007 (2013.01); A61L 2/0023 (2013.01); A61L 2/0035 (2013.01); C12N 5/0018 (2013.01); C12N 13/00 (2013.01); C12N 2500/32 (2013.01); C12N 2500/34 (2013.01); C12N 2500/38 (2013.01); C12N 2523/00 (2013.01);
Abstract

The invention discloses a method for virus clearance of a cell culture medium, comprising the steps of: i) providing a bulk medium portion, comprising amino acids and glucose, and a first additive portion, comprising vitamins in aqueous solution; ii) subjecting the bulk medium portion to a high temperature short time treatment (HTST); iii) passing the first additive portion through a virus retentive filter or an ultrafilter; and iv) after steps ii) and iii), mixing the bulk medium portion with the first additive portion to obtain a cell culture medium.


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