The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2021
Filed:
Nov. 05, 2013
Applicant:
Amgen Inc., Thousand Oaks, CA (US);
Inventors:
Carsten Olbrich, Berlin, DE;
Thomas Bunte, Berlin, DE;
Jonas Winter, Berlin, DE;
Jörg Peters, Berlin, DE;
Thomas Trill, Berlin, DE;
Assignee:
AMGEN INC., Thousand Oaks, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/00 (2006.01); A61K 38/17 (2006.01); C07K 16/30 (2006.01); C07K 16/28 (2006.01); A61K 39/395 (2006.01);
U.S. Cl.
CPC ...
A61K 38/17 (2013.01); A61K 39/39591 (2013.01); C07K 16/2809 (2013.01); C07K 16/3069 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01);
Abstract
The present invention relates to stable pharmaceutical compositions which contain polypeptides having at least two antigen-binding domains and are especially suited for subcutaneous administration. The invention provides liquid compositions which minimize the formation of undesired polypeptide aggregates (dimers and/or multimers). The present invention further provides a method for minimizing the aggregation of polypeptides having antigen-binding domains in liquid compositions.