The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 06, 2021
Filed:
May. 24, 2018
Applicant:
Sun Yat-sen University, Guangdong, CN;
Inventors:
Assignee:
SUN YAT-SEN UNIVERSITY, Guangzhou, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 35/52 (2015.01); C12N 5/071 (2010.01); A61K 45/00 (2006.01); A61P 5/26 (2006.01); C12N 5/0735 (2010.01); A61K 38/18 (2006.01);
U.S. Cl.
CPC ...
A61K 35/52 (2013.01); A61K 45/00 (2013.01); A61P 5/26 (2018.01); C12N 5/0606 (2013.01); C12N 5/0683 (2013.01); A61K 38/1808 (2013.01); A61K 38/1825 (2013.01); C12N 2500/32 (2013.01); C12N 2500/44 (2013.01); C12N 2500/99 (2013.01); C12N 2501/105 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/135 (2013.01); C12N 2501/31 (2013.01); C12N 2501/395 (2013.01); C12N 2501/727 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01); C12N 2533/32 (2013.01); C12N 2533/52 (2013.01); C12N 2533/54 (2013.01);
Abstract
The present application provides an in-vitro committed differentiation method for inducing human induced pluripotent stem cells (hiPSCs) into Leydig cells (LCs) by neural crest stem cells (NCSCs). The hiPS-derived LCs is verified by an animal model to have the capacity of regenerating senile or injured LCs, so that a new treatment for supplementing testosterone is provided for patients suffering from hypogonadism, particularly for patients suffering from late-onset hypogonadism (LOH).