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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11052076 B1

PDFFull Text
Date of Patent:
Jul. 06, 2021

Filed:

Jun. 12, 2018

Spirocyclic indolines as il-17 modulators

Applicant:

Ucb Biopharma Srl, Brussels, BE;

Inventors:

Gareth Neil Brace, Abingdon, GB;

Rose Elizabeth Chappell, Abingdon, GB;

Hervé Jean Claude Deboves, Abingdon, GB;

Anne Marie Foley, Slough, GB;

Gregory Foulkes, Abingdon, GB;

Elizabeth Pearl Jones, Bracknell, GB;

Fabien Claude Lecomte, Slough, GB;

Joanna Rachel Quincey, Slough, GB;

Monika-Sarah Elisabeth Dorothea Schulze, Slough, GB;

Matthew Duncan Selby, Slough, GB;

Adam Peter Smalley, Slough, GB;

Richard David Taylor, Slough, GB;

Robert James Townsend, Abingdon, GB;

Zhaoning Zhu, Slough, GB;

Assignee:

UCB Biopharma SRL, Brussels, BE;

Attorney:

McDonnell Boehnen Hulbert & Berghoff LLP

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 471/10 (2006.01); C07D 487/10 (2006.01); C07D 495/10 (2006.01); C07D 491/20 (2006.01); A61K 31/4439 (2006.01); A61K 31/407 (2006.01); A61K 31/4155 (2006.01); A61K 31/4192 (2006.01); A61K 31/4196 (2006.01); A61K 31/422 (2006.01); A61K 31/427 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01); A61K 31/501 (2006.01); A61K 31/502 (2006.01); A61K 31/506 (2006.01); C07D 491/107 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/407 (2013.01); A61K 31/4155 (2013.01); A61K 31/4192 (2013.01); A61K 31/4196 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/501 (2013.01); A61K 31/502 (2013.01); A61K 31/506 (2013.01); C07D 471/10 (2013.01); C07D 487/10 (2013.01); C07D 491/107 (2013.01); C07D 491/20 (2013.01); C07D 495/10 (2013.01); C07D 519/00 (2013.01);
Abstract

A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

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