The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2021
Filed:
Aug. 04, 2015
Synaffix B.v., Oss, NL;
Anna Agnieszka Wasiel, Utrecht, NL;
Floris Louis Van Delft, Nijmegen, NL;
Sander Sebastiaan Van Berkel, Lent, NL;
SYNAFFIX B.V., Oss, NL;
Abstract
The present invention relates to a process for the modification of a glycoprotein, using a β-(1,4)-N-acetylgalactosaminyltransferase or a mutant thereof. The process comprises the step of contacting a glycoprotein comprising a glycan comprising a terminal GlcNAc-moiety, in the presence of a β-(1,4)-N-acetylgalactosaminyltransferase or a mutant thereof, with anon-natural sugar-derivative nucleotide. The non-natural sugar-derivative nucleotideis according to formula (3), wherein A is selected from the group consisting of —N; —C(O)R; —C═C—R; —SH; —SC(O)R; —SC(V)OR, wherein V is O or S; —X wherein X is selected from the group consisting of F, Cl, Br and I; —OS(O)R; an optionally substituted C-Calkyl group; an optionally substituted terminal C-Calkenyl group; and an optionally substituted terminal C-Calkenyl group.