The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2021
Filed:
Jul. 14, 2015
Biontech SE, Mainz, DE;
Tron—translationale Onkologie an Der Universitatsmedizin Der Johannes Gutenberg-universitat Mainz Ggmbh, Mainz, DE;
Jpt Peptides Technologies Gmbh, Berlin, DE;
Ugur Sahin, Mainz, DE;
Laura Marie Kring, Munich, DE;
Markus Fiedler, Halle an der Saale, DE;
Matin Daneschdar, Budenheim, DE;
Hans-Ulrich Schmoldt, Klein-Winternheim, DE;
Ulf Reimer, Berlin, DE;
Karsten Schnatbaum, Berlin, DE;
BioNTech SE, Mainz, DE;
TRON-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH, Mainz, DE;
JPT Peptide Technologies GmbH, Berlin, DE;
Abstract
The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3ε). These molecules compete with CD3ε for binding to a CD3ε binding domain. e.g. a CD3ε binding domain of an antibody, and are capable of detecting antibodies against CD3ε. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3ε antibody purification and the detection of anti-CD3ε antibodies in biological samples.