The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 29, 2021
Filed:
Feb. 02, 2018
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Shaomeng Wang, Superior Township, MI (US);
Jiantao Hu, Ann Arbor, MI (US);
Fuming Xu, Ann Arbor, MI (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 498/12 (2006.01); C07D 498/04 (2006.01); C07D 495/14 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 498/12 (2013.01); C07D 487/04 (2013.01); C07D 495/14 (2013.01); C07D 498/04 (2013.01);
Abstract
The present disclosure provides fused 1,4-diazepines represented by Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein A, E, R, R, R, R, R, and Ar are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds having Formula (I) to treat diseases, conditions, or disorders responsive to inhibition of BET bromodomain proteins such as cancer.