The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 29, 2021

Filed:

Nov. 03, 2017
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Ning Chen, Thousand Oaks, CA (US);

Xiaoqi Chen, Palo Alto, CA (US);

Yinhong Chen, Hayward, CA (US);

Alan C. Cheng, San Francisco, CA (US);

Richard V. Connors, Mesa, AZ (US);

Jeffrey Deignan, San Francisco, CA (US);

Paul John Dransfield, Arlington, MA (US);

Xiaohui Du, Belmont, CA (US);

Zice Fu, Foster City, CA (US);

James S. Harvey, Arlington, MA (US);

Julie Anne Heath, Chico, CA (US);

Lars V. Heumann, Redwood City, CA (US);

Daniel B. Horne, Natick, MA (US);

Jonathan Houze, Cambridge, MA (US);

Matthew R. Kaller, Ventura, CA (US);

Frank Kayser, San Francisco, CA (US);

Aarif Yusuf Khakoo, Woodside, CA (US);

David J. Kopecky, Washington D.C., DC (US);

Su-Jen Lai, Cambridge, MA (US);

Zhihua Ma, Lexington, MA (US);

Julio C. Medina, San Carlos, CA (US);

Jeffrey T. Mihalic, San Francisco, CA (US);

Nobuko Nishimura, West Hills, CA (US);

Steven H. Olson, Millbrae, CA (US);

Vatee Pattaropong, Bedford, MA (US);

Gayathri Swaminath, Brisbane, CA (US);

Xiaodong Wang, Johns Creek, GA (US);

Malgorzata Wanska, Camarillo, CA (US);

Kevin Yang, San Gabriel, CA (US);

Wen-Chen Yeh, Belmont, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/14 (2006.01); A61P 9/00 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 409/04 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61P 9/00 (2018.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 409/04 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 417/04 (2013.01);
Abstract

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.


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