The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 29, 2021

Filed:

Sep. 21, 2018
Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Yang Wei, Yorktown Heights, NY (US);

Haruka Okamoto, New York, NY (US);

Jesper Gromada, Scarsdale, NY (US);

Samuel Davis, New York, NY (US);

Andrew J. Murphy, Croton-on-Hudson, NY (US);

Assignee:

Regeneren Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/26 (2006.01); C07K 16/28 (2006.01); C07K 14/605 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61K 31/155 (2006.01); A61K 31/5415 (2006.01); C07K 16/08 (2006.01); C12N 15/62 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/26 (2013.01); A61K 31/155 (2013.01); A61K 31/5415 (2013.01); A61P 3/04 (2018.01); A61P 3/10 (2018.01); C07K 14/605 (2013.01); C07K 16/082 (2013.01); C07K 16/2869 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract

The present invention provides modified glucagon-like peptide 1 (GLP1) polypeptides, fusion proteins comprising modified GLP1 polypeptides, and methods of use thereof. In various embodiments of the invention, the fusion proteins are GLP1 receptor agonists that comprise a modified GLP1 fused to a stabilizing domain. In some embodiments, the fusion proteins comprising modified GLP1 are useful for treating or ameliorating a symptom or indication of a disorder such as obesity and diabetes.


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