logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11045478 B1

PDFFull Text
Date of Patent:
Jun. 29, 2021

Filed:

Nov. 11, 2019

Salts of potassium atp channel openers and uses thereof

Applicant:

Essentialis, Inc., Redwood City, CA (US);

Inventors:

Neil M. Cowen, Carlsbad, CA (US);

Khaled A. Yamout, Carlsbad, CA (US);

Assignee:

ESSENTIALIS, INC., Redwood City, CA (US);

Attorney:

Cooley LLP

Primary Examiner:

Jeffrey S Lundgren

Assistant Examiner:

Chris E Simmons

Int. Cl.
CPC ...
A61K 31/137 (2006.01); A61K 31/365 (2006.01); A61K 31/42 (2006.01); A61K 31/357 (2006.01); A61K 31/4355 (2006.01); A61K 31/549 (2006.01); A61P 3/10 (2006.01); A61P 3/04 (2006.01); A61K 31/54 (2006.01); C07D 285/24 (2006.01); C07C 209/68 (2006.01); C07C 213/08 (2006.01); A61K 9/20 (2006.01); A61K 45/06 (2006.01); A61K 38/27 (2006.01);
U.S. Cl.
CPC ...
A61K 31/549 (2013.01); A61K 9/2086 (2013.01); A61K 31/54 (2013.01); A61K 38/27 (2013.01); A61K 45/06 (2013.01); C07C 209/68 (2013.01); C07C 213/08 (2013.01); C07D 285/24 (2013.01);
Abstract

Provided are immediate or prolonged administration of certain salts of Kchannel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving Kchannels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

Find Patent Forward Citations

Loading…