The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 22, 2021

Filed:

May. 11, 2018
Applicants:

The Trustees of Columbia University IN the City of New York, New York, NY (US);

Research Foundation for Mental Hygiene, Inc., Menands, NY (US);

Inventors:

Catherine L. Clelland, New York, NY (US);

James D. Clelland, New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/6883 (2018.01); A61K 31/19 (2006.01); A61K 31/198 (2006.01); A61P 25/18 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/19 (2013.01); A61K 31/198 (2013.01); A61P 25/18 (2018.01); G01N 33/6896 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); G01N 2800/28 (2013.01); G01N 2800/302 (2013.01); G01N 2800/304 (2013.01); G01N 2800/307 (2013.01); G01N 2800/52 (2013.01);
Abstract

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disorder, such as schizophrenia or bipolar disorder, by increasing or decreasing proline levels. Further provided are methods of predicting and monitoring the clinical response in a patient, and diagnostic systems for identifying a patient likely to benefit from proline modulation.


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