The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Mar. 31, 2017
The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Rockville, MD (US);
Thomas Jefferson University, Harleysville, PA (US);
University of Maryland, Baltimore, MD (US);
Reed F. Johnson, Frederick, MD (US);
Matthias Schnell, Harleysville, PA (US);
Lisa E. Hensley, Frederick, MD (US);
Christoph Wirblich, Philadelphia, PA (US);
Christopher M. Coleman, Owings Mills, MD (US);
Matthew B. Frieman, Baltimore, MD (US);
Thomas Jefferson University, Philadelphia, PA (US);
The United States of America, as represented by the Secretary, Department of Health & Human Service, Rockville, MD (US);
University of Maryland, Baltimore, MD (US);
Abstract
The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.