The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Jun. 01, 2018
Applicant:
Jiangnan University, Wuxi, CN;
Inventors:
Jinsong Shi, Wuxi, CN;
Zhenghong Xu, Wuxi, CN;
Jinsong Gong, Wuxi, CN;
Heng Li, Wuxi, CN;
Chang Su, Wuxi, CN;
Assignee:
JIANGNAN UNIVERSITY, Wuxi, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/77 (2006.01); C12N 9/64 (2006.01); C12R 1/13 (2006.01);
U.S. Cl.
CPC ...
C12N 15/77 (2013.01); C12N 9/6424 (2013.01); C12R 1/13 (2013.01);
Abstract
The invention relates to the technical field of industrial biotechnologies, and discloses a keratinase mutant with improved thermal stability and use thereof. The asparagine at position 181, the tyrosine at position 217, and the serine at position 236 in the keratinase derived from(CGMCC No. 10798) are engineered by site-direction mutation, and combined at random to obtain an enzyme with combined mutations. The invention realizes the remarkable improvement of the thermal stability of keratinase, and has good theoretical value and application prospect.