The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
May. 04, 2018
Antisense Therapeutics Ltd, Toorak, AU;
Children's Hospital of Los Angeles, Los Angeles, CA (US);
George Tachas, Kew, AU;
Yong-Mi Kim, Los Angeles, CA (US);
Antisense Therapeutics Ltd, Toorak, AU;
Children's Hospital of Los Angeles, Los Angeles, CA (US);
Abstract
A method for mobilizing leukemia cells which are α4 integrin positive to the peripheral blood of a human subject, the method comprising administering to the human subject an effective amount of an antisense compound to α4 integrin. The cells may be mobilized from bone marrow. The antisense compound is: 5'-CUG AGTCTG TTTUCC AUUCU-3′ wherein, (a) each of the 19 internucleotide linkages of the oligonucleotide is an O,O-linked phosphorothioate diester; (b) the nucleotides at the positions 1 to 3 from the 5′ end are 2′-O-(2-methoxyethyl) modified ribonucleosides; (c) the nucleotides at the positions 4 to 12 from the 5′ end are 2′-deoxyribonucleosides; (d) the nucleotides at the positions 13 to 20 from the 5′ end are 2′-O-(2-methoxyethyl) modified ribonucleosides; and (e) all cytosines are 5-methylcytosines (C), or a pharmaceutically acceptable salt thereof.