The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Apr. 12, 2017
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Assistance Publique-hôpitaux DE Paris (Aphp), Paris, FR;
Université Paris Diderot—paris 7, Paris, FR;
Institut Pasteur, Paris, FR;
Université Paris Xiii Paris-nord, Villetaneuse, FR;
Jean-Damien Ricard, Paris, FR;
Olivier Clermont, Paris, FR;
Laurent Debarbieux, Paris, FR;
Erick Denamur, Paris, FR;
Nicolas Dufour, Cergy-Pontoise, FR;
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, Paris, FR;
ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), Paris, FR;
UNIVERSITÉ PARIS DIDEROT—PARIS 7, Paris, FR;
UNIVERSITÉ PARIS XIII PARIS-NORD, Villentaneuse, FR;
Abstract
The present invention relates to a bacteriophage strain capable of producing a lytic infection in theST131-025b:H4 clone. The burden of ST131-025b:H4clonal complex in human community and hospital-acquired infections is increasing worldwide, going along with a worrying and growing resistance to betalactams and fluoroquinolones. Bacteriophage LM33_P1 infects exclusively (100% specificity) 025bstrains with 70% coverage on the two major antibiotic resistant pandemic clonal complexes ST131-025b:H4 and ST69-025b. The inventors evaluated the in vivo activity of bacteriophage LM33_P1 using three different extraintestinal virulence murine models and showed that it infects bacteria in several organs. In particular, the invention relates to a bacteriophage capable of producing a lytic infection in theST131-025b:H4 clone comprising a polypeptide corresponding to the bacteriophage tail fiber protein and responsible for the attachment of the bacteriophage to theST131-025b:H4 clone.