The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Jul. 03, 2018
Uniwersytet Warszawski, Warsaw, PL;
Instytut Farmakologii Polskiej Akademii Nauk, Cracow, PL;
Aleksandra Misicka-Kesik, Piastow, PL;
Ewa Witkowska, Zielonka, PL;
Beata Wilenska, Warsaw, PL;
Barbara Przewlocka, Cracow, PL;
Joanna Mika, Cracow, PL;
Joanna Starnowska-Sokol, Miechów, PL;
Anna Piotrowska-Murzyn, Zielonki, PL;
Uniwersytet Warszawski, Warsaw, PL;
Instytut Farmakologii Polskiej Akademii Nauk, Cracow, PL;
Abstract
The invention pertains to novel hybrid peptidomimetics, pharmaceutical composition comprising thereof and use thereof in the treatment of neuropathic pain. The hybrid peptidomimetics according to the invention are comprised of two components: an opioid receptor agonist (OP) and a MC4 receptor antagonist, connected by a linker. The compounds of such a structure will allow to activate opioid receptors with simultaneous blocking of melanocortin type 4 receptors (MC4), which results in enhancing efficiency of the opioid therapy in neuropathic pain.