The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Mar. 19, 2018
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Danqing Feng, Green Brook, NJ (US);
Pei Huo, Millburn, NJ (US);
Ahmet Kekec, Hoboken, NJ (US);
Songnian Lin, Holmdel, NJ (US);
Christopher R. Moyes, Westfiled, NJ (US);
Ravi Nargund, Skillman, NJ (US);
Brenda Pipik, Edison, NJ (US);
Dmitri A. Pissarnitski, Scotch Plains, NJ (US);
Lin Yan, East Brunswick, NJ (US);
Yuping Zhu, Basking Ridge, NJ (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
An insulin conjugate comprising or consisting of a tri-valent sugar cluster is described. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.