The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
May. 31, 2018
Applicant:
Nucana Plc, Edinburgh, GB;
Inventors:
Christopher McGuigan, Cardiff, GB;
Fabrizio Pertusati, Cardiff, GB;
Assignee:
NuCana plc, Edinburgh, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 19/20 (2006.01); C07H 1/00 (2006.01); C07H 19/06 (2006.01); C07H 19/16 (2006.01); B82Y 20/00 (2011.01); B01J 27/128 (2006.01); C07H 19/10 (2006.01); H01S 5/343 (2006.01);
U.S. Cl.
CPC ...
C07H 19/20 (2013.01); B01J 27/128 (2013.01); B82Y 20/00 (2013.01); C07H 1/00 (2013.01); C07H 19/06 (2013.01); C07H 19/10 (2013.01); C07H 19/16 (2013.01); H01S 5/34326 (2013.01);
Abstract
Provided are phosphoramidate nucleoside compounds of Formula (I), or pharmaceutically acceptable salts or esters or solvates thereof, useful in the treatment of cancer, viral infections and other diseases: Also provided is a process for the synthesis of compounds of Formula (I) where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu, Fe, La and Yb.