The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Jun. 05, 2019
Applicant:
Agency for Science, Technology, and Research, Singapore, SG;
Inventors:
Kassoum Nacro, Singapore, SG;
Athisayamani Jeyaraj Duraiswamy, Singapore, SG;
Lohitha Rao Chennamaneni, Singapore, SG;
Assignee:
Agency for Science, Technology and Research, Connexis, SG;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 235/06 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01); A61K 45/06 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01); A61K 31/4985 (2006.01); A61K 31/5025 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01); A61K 31/4545 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/551 (2006.01); A61K 31/553 (2006.01); C07D 471/10 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 31/4545 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/551 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 235/06 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 491/107 (2013.01); C07D 519/00 (2013.01);
Abstract
The present invention relates to compounds of Formula (Ib-I) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.