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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11040963 B1

PDFFull Text
Date of Patent:
Jun. 22, 2021

Filed:

Feb. 01, 2018

Piperazine derivatives for influenza virus inhibitions

Applicant:

Janssen Vaccines & Prevision B.v., Leiden, NL;

Inventors:

Maria Van Dongen, Hilversum, NL;

Jaroslaw Juraszek, Amsterdam, NL;

Griet Wim Bert Schepens, Sint-Katelijne-Waver, BE;

Charles Edward Lawson, Pipersville, PA (US);

Brian Shook, Holliston, MA (US);

Maria Tim Hugo Jonckers, Heist-op-den-Berg, BE;

Abdellah Tahri, Anderlecht, BE;

Bernard Pierre Jean-Marie Raboisson, Rosieres, BE;

Nestor CHristophe Francis Robert Buyck, Hamme, BE;

Assignee:

JANSSEN VACCINES & PREVENTION B.V., Leiden, NL;

Attorney:

Kramer Amado, P.C.

Primary Examiner:

Noble E Jarrell

Int. Cl.
CPC ...
C07D 413/10 (2006.01); A61P 31/16 (2006.01); C07D 401/10 (2006.01); C07D 413/14 (2006.01); C07D 417/10 (2006.01); C07D 417/14 (2006.01); C07D 487/08 (2006.01); C07D 498/04 (2006.01); C07D 263/57 (2006.01); C07D 413/12 (2006.01); C07D 277/66 (2006.01); C07D 417/12 (2006.01); C07D 295/108 (2006.01); C07D 307/79 (2006.01); C07D 235/18 (2006.01);
U.S. Cl.
CPC ...
C07D 413/10 (2013.01); A61P 31/16 (2018.01); C07D 235/18 (2013.01); C07D 263/57 (2013.01); C07D 277/66 (2013.01); C07D 295/108 (2013.01); C07D 307/79 (2013.01); C07D 401/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07D 487/08 (2013.01); C07D 498/04 (2013.01);
Abstract

The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.

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