The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 22, 2021
Filed:
Jun. 29, 2017
The Scripps Research Institute, La Jolla, CA (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
Bruce Beutler, Dallas, TX (US);
Dale L. Boger, La Jolla, CA (US);
Bruce Beutler, Dallas, TX (US);
Dale L. Boger, La Jolla, CA (US);
The Board of Regents of the University of Texas System, Austin, TX (US);
The Scripps Research Institute, La Jolla, CA (US);
Abstract
A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R, R, Rand R(when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.