The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2021
Filed:
Feb. 06, 2018
Applicant:
Ipsen Bioinnovation, Limited, Abingdon, Oxfordshire, GB;
Inventors:
Assignee:
IPSEN BIOINNOVATION LIMITED, Abingdon, GB;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/52 (2006.01); C07K 14/33 (2006.01); A61K 38/48 (2006.01);
U.S. Cl.
CPC ...
C12N 9/52 (2013.01); A61K 38/4886 (2013.01); A61K 38/4893 (2013.01); C07K 14/33 (2013.01); C12Y 304/24068 (2013.01); C12Y 304/24069 (2013.01);
Abstract
The present invention provides an engineered clostridial toxin comprising at least one amino acid modification, wherein said at least one amino acid modification increases the isoelectric point (pI) of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the pI of an otherwise identical clostridial toxin lacking said at least one amino acid modification. Also provided are corresponding uses of the engineered clostridial toxin in therapy.