The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2021
Filed:
Apr. 02, 2018
Applicant:
Bioasis Technologies, Inc., Guilford, CT (US);
Inventors:
Timothy Z. Vitalis, Vancouver, CA;
Reinhard Gabathuler, Montreal, CA;
Assignee:
biOasis Technologies, Inc., Vancouver, CA;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/16 (2006.01); A61K 47/64 (2017.01); A61K 38/00 (2006.01); C12N 11/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/16 (2013.01); A61K 47/644 (2017.08); C12N 11/00 (2013.01); A61K 38/00 (2013.01);
Abstract
Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS, or I2D) and iduronidase (IDU), having increased ability to traverse or penetrate the blood brain barrier (BBB) relative to phosphorylated forms of the protein, and p97 conjugates thereof. Also provided are compositions comprising such dephosphorylated LSD proteins and p97 conjugates, and methods of use thereof, for instance, to treat any one or more lysosomal storage diseases, such as Hunter Syndrome (or MPS Type II).