The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 15, 2021

Filed:

Apr. 08, 2019
Applicant:

Prolume, Ltd., Pinetop, AZ (US);

Inventors:

Bruce Bryan, Beverly Hills, CA (US);

Hendrik Schmidt, Denver, CO (US);

Millard Cull, Brighton, CO (US);

Assignee:

Prolume, LTD., Pinetop, AZ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/22 (2006.01); C09K 11/07 (2006.01); C12N 9/02 (2006.01); A61K 38/17 (2006.01); A61K 38/44 (2006.01); A63J 5/02 (2006.01); C07D 487/04 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C09K 11/07 (2013.01); A61K 38/1767 (2013.01); A61K 38/44 (2013.01); A61K 49/0045 (2013.01); A63J 5/02 (2013.01); C07D 487/04 (2013.01); C12N 9/0069 (2013.01); C12Y 113/12007 (2013.01); C09K 2211/1007 (2013.01); C09K 2211/1018 (2013.01); C09K 2211/14 (2013.01);
Abstract

Novel compounds in the classes of Imidazo[1,2-α]pyrazines and Imidazo[1,2-α]quinoxalines with a methoxy group modification show unique spectral properties when used as a substrate for luciferases and photo-proteins. Methoxy e-Coelenterazine, an Imidazo[1,2-α] quinoxaline shifts the emission wavelength by 80 nm to blue light compared to e-Coelenterazine, usingluciferase. The novel analogues described here are useful in combination with fluorescent proteins to create BRET (bioluminescent resonance energy transfer) and for other luminescent assays. In addition these novel compounds can be used to enhance, dazzle, amaze, startle, and otherwise entertain an audience by their direct application on to the audience, surroundings, the actors, or sprayed on settings as in the newer 4D movies.


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