The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2021
Filed:
Oct. 28, 2019
Applicant:
Myokardia, Inc., South San Francisco, CA (US);
Inventors:
Mark Grillo, San Francisco, CA (US);
Brian Kane, San Mateo, CA (US);
Johan Oslob, Sunnyvale, CA (US);
Min Zhong, Palo Alto, CA (US);
Fabienne Thompson, Paris, FR;
Assignee:
MyoKardia, Inc., Brisbane, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01);
Abstract
The present disclosure provides novel 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4-diones of formula (I): The compounds of formula (I) are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.