The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 15, 2021

Filed:

Apr. 17, 2020
Applicant:

Black Diamond Therapeutics, Inc., Cambridge, MA (US);

Inventors:

Alexander Flohr, Basel, CH;

Alexander Mayweg, Stony Brook, NY (US);

George Trainor, Stony Brook, NY (US);

David M. Epstein, Philadelphia, PA (US);

Matthew O'Connor, Massapequa Park, NY (US);

Elizabeth Buck, Huntington, NY (US);

Luca Arista, Riehen, CH;

Assignee:

Black Diamond Therapeutics, Inc., Cambridge, MA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 487/04 (2006.01); C07D 491/04 (2006.01); C07D 491/08 (2006.01); C07D 239/74 (2006.01); C07D 401/12 (2006.01); C07D 295/13 (2006.01); C07D 295/088 (2006.01); C07D 405/14 (2006.01); C07D 487/08 (2006.01); C07D 491/107 (2006.01); C07D 471/08 (2006.01); C07D 487/10 (2006.01); C07D 491/048 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); C07D 239/74 (2013.01); C07D 295/088 (2013.01); C07D 295/13 (2013.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 417/14 (2013.01); C07D 471/08 (2013.01); C07D 487/04 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 491/048 (2013.01); C07D 491/08 (2013.01); C07D 491/107 (2013.01);
Abstract

The present disclosure relates to new compounds or pharmaceutically acceptable salts or stereoisomers thereof of formula I as inhibitors of receptor tyrosine kinases (RTK), in particular extracellular mutants of ErbB-receptors. The present disclosure also relates to methods of preparation these compounds, compositions comprising these compounds, and methods of using them in the treatment of cancer in mammals (e.g. humans).


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