The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2021
Filed:
Mar. 18, 2015
Universitat Zurich, Zurich, CH;
Universitatsspital Basel, Basel, CH;
Malay Patra, Cambridge, MA (US);
Gilles Gasser, Zug, CH;
Thomas L. Mindt, Basel, CH;
Andreas Bauman, Schopfheim, DE;
UNIVERSITAT ZURICH, Zurich, CH;
UNIVERSITATSSPITAL BASEL, Basel, CH;
Abstract
The invention relates to octadentate ligands of a general formula R-D-X-D-X-D-X-D-E-R, wherein D is C(O)N(OH) or N(OH)C(O), pyrimidinone or pyridinone, each X independently of any other X is a saturated or partially unsaturated, substituted or unsubstituted linker comprising 8-11 atoms selected from any of N, C, O; Ris alkyl, cycloalkyl, arene, or heteroarene, E is a saturated or partially unsaturated, substituted or unsubstituted chain comprising 1-50 atoms and Ris a moiety capable of selectively binding to a biomolecule, or a nanoparticle. The invention further relates to complexes of the ligand, particularly radionuclides and their use in radioimmunotherapy and imaging.