The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 15, 2021
Filed:
May. 11, 2018
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/51 (2006.01); A61K 47/60 (2017.01); C12N 9/96 (2006.01); A61K 9/00 (2006.01); A61P 7/00 (2006.01); C12N 15/70 (2006.01); C12N 15/861 (2006.01); C12N 15/869 (2006.01); C12N 15/867 (2006.01); C12N 15/80 (2006.01); C12N 9/88 (2006.01); A61K 9/19 (2006.01); A61K 31/4415 (2006.01); A61K 31/198 (2006.01);
U.S. Cl.
CPC ...
A61K 38/51 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 47/60 (2017.08); A61P 7/00 (2018.01); C12N 9/88 (2013.01); C12N 9/96 (2013.01); C12N 15/70 (2013.01); C12N 15/80 (2013.01); C12N 15/861 (2013.01); C12N 15/867 (2013.01); C12N 15/869 (2013.01); C12Y 404/01001 (2013.01); A61K 31/198 (2013.01); A61K 31/4415 (2013.01);
Abstract
Methods and compositions relating to the engineering of an improved protein with homocyst(e)inase enzyme activity are described. For example, there are disclosed modified cystathionine-γ-lyase (CGL) enzymes comprising one or more amino acid substitutions and capable of degrading homocyst(e)ine. Furthermore, provided are compositions and methods for the treatment of homocystinuria or hyperhomocysteinemia with homocyst(e)ine depletion using the disclosed enzymes or nucleic acids.