The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 15, 2021

Filed:

Aug. 23, 2013
Applicant:

Riken, Wako, JP;

Inventors:

Masayo Takahashi, Wako, JP;

Hiroyuki Kamao, Wako, JP;

Assignee:

RIKEN, Wako, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/44 (2015.01); C12N 5/071 (2010.01); A61L 27/38 (2006.01); C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
A61K 35/44 (2013.01); A61L 27/3808 (2013.01); A61L 27/3834 (2013.01); A61L 27/3891 (2013.01); C12N 5/069 (2013.01); C12N 5/0621 (2013.01); C12N 5/0697 (2013.01); A61L 2430/16 (2013.01); C12N 2502/085 (2013.01); C12N 2502/28 (2013.01); C12N 2509/00 (2013.01); C12N 2533/54 (2013.01);
Abstract

The present invention provides a method of producing a cell sheet comprising a retinal pigment epithelial cell layer and a vascular forming cell layer composed of stem cells having vascular formation ability or blood vessel constituting cells, comprising a step of laminating the retinal pigment epithelial cell layer and the vascular forming cell layer, and a cell sheet obtained by said method. Furthermore, the present invention provides a cell sheet for transplantation, comprising a cell layer formed with retinal pigment epithelial cells obtained by inducing differentiation of stem cells or progenitor cells ex vivo, a basement membrane secreted from said cells, and a vascular forming cell layer composed of stem cells having vascular formation ability or blood vessel constituting cells.


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