The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Aug. 28, 2017
Hunan Agricultural University, Changsha, CN;
Tiean Zhou, Changsha, CN;
Lun Xiong, Changsha, CN;
Zhen Zhou, Changsha, CN;
Jingyuan Huang, Changsha, CN;
Haibo Shen, Changsha, CN;
Dongqin Bao, Changsha, CN;
Fushen Huang, Changsha, CN;
Kebin Wu, Changsha, CN;
Weisong Pan, Changsha, CN;
Jia Zhao, Changsha, CN;
Bin Hong, Changsha, CN;
HUNAN AGRICULTURAL UNIVERSITY, Changsha, CN;
Abstract
A real time and quantitative method of measuring traction force of living cells include the following procedures. Place AT-cut and BT-cut quartz crystals of the same frequency, surface morphology and/or modified with the same cell adhesion molecules in petri dishes or detection cells; add the cells to the petri dishes or detection cells, the cell traction force at arbitrary time t during adhesion of the cells or under different internal/external environmental stimulations is estimated by the following equation: ΔS=(K−K)[tΔf/fr−tqΔf/fr]. The method can be used to track the dynamic changes of cells generated force during the adhesion of cells and under different internal/external environmental stimulations, such as the effects of drugs. The drugs can be added before or after the adhesion of the cells. This method is suitable for all adherent cells, including primary cells and passage cells.