The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Sep. 22, 2016
Applicant:
Biocartis NV, Mechelen, BE;
Inventors:
Bart Claes, Mechelen, BE;
Rudi Rossau, Mechelen, BE;
Assignee:
BIOCARTIS, NV, Mechelen, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6858 (2018.01); C12Q 1/6886 (2018.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6858 (2013.01); C12N 15/11 (2013.01); C12Q 1/6886 (2013.01); C12N 2310/313 (2013.01); C12N 2310/3517 (2013.01); C12Q 2527/107 (2013.01); C12Q 2537/143 (2013.01); C12Q 2565/1025 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present application relates to detection of changes in the number of nucleotides in short homopolymeric nucleic acid repeats, in particular in short homopolymeric microsatellites, for example for the purpose of diagnosing microsatellite instability (MSI) and/or mismatch repair (MMR-) deficiency in tumors. Accordingly, methods are provided for detecting changes in the number of nucleotides present in short homopolymeric nucleotide repeat sequences as well as kits and cartridges for automated detection of said changes.