The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Mar. 15, 2019
Glympse Bio, Inc., Cambridge, MA (US);
Sangeeta Bhatia, Lexington, MA (US);
Gabriel Kwong, Atlanta, GA (US);
Eric Huang, Lexington, MA (US);
Sirshendu Roopom Banerjee, Lexington, MA (US);
Andrew Warren, Cambridge, MA (US);
Sophie Cazanave, Cambridge, MA (US);
GLYMPSE BIO, INC., Cambridge, MA (US);
Abstract
Methods and compositions for screening or diagnosis of liver disease are provided. The results may also indicate course and efficacy of treatment. The composition includes an activity sensor and a reporter releasably attached to the activity sensor. The method includes detecting the presence and/or amount of a reporter. The reporter is released from an activity sensor in the presence of diseased liver tissue but remains attached to the activity sensor in healthy tissue. The presence and/or amount of the reporter are used to characterize the liver disease. The liver disease may be nonalcoholic steatohepatitis (NASH) and results may further indicate staging of NASH.