The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 08, 2021
Filed:
Jun. 08, 2020
Applicant:
Portola Pharmaceuticals, Inc., South San Francisco, CA (US);
Inventors:
Juan Wang, Foster City, CA (US);
Gregory A. Sacha, Bargersville, IN (US);
Phuong M. Nguyen, Burlingame, CA (US);
Assignee:
Alexion Pharmaceuticals, Inc., Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C12N 9/64 (2006.01); A61K 9/00 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 9/19 (2006.01); A61K 38/48 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6432 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 38/4846 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 14/00 (2013.01); C12Y 304/21006 (2013.01);
Abstract
The present disclosure relates to solutions and methods of preparing lyophilized formulations of factor Xa (fXa) antidotes. A suitable aqueous formulation suitable for lyophilization can include a fXa antidote, a solubilizing agent, a stabilizer, and a crystalline component, wherein the formulation does not collapse during lyophilization.